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Personalized Immunology in Cancer: Paving the Way Towards a Better Quality of Life
Conventionally, in specific diseases, patients receive similar therapies; relying on a "one size fits all" approach. The discovery of P5 (Predictive, Preventive, Personalized, Participatory, and psycho-cognitive) improves personalized diagnosis, treatment, and prognosis. Considering the high prevalence, mortality rate, and complexity of cancers, there is a critical necessity to choose specific ...
متن کاملHuman Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملPersonalized Immunology in Cancer: Paving the Way Towards a Better Quality of Life
Conventionally, in specific diseases, patients receive similar therapies; relying on a "one size fits all" approach. The discovery of P5 (Predictive, Preventive, Personalized, Participatory, and psycho-cognitive) improves personalized diagnosis, treatment, and prognosis. Considering the high prevalence, mortality rate, and complexity of cancers, there is a critical necessity to choose specific ...
متن کاملHuman Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملFeasibility assessment of in vitro chemoresponse assay on stereotactic biopsies of glioblastoma multiforms: a step towards personalized medicine
Objective(s):P In vitro chemosensitivity and resistance assays (CSRAs) are a promising tool for personalized treatment of glioblastoma multiform (GBM). These assays require a minimum of 1 to 2 g of tumor specimen for testing, but this amount is not always accessible. We aimed to assess the feasibility and validity of utilizing stereotactic biopsies of GBM in CSRAs. Materials and Methods: Single...
متن کاملThe rocky road to personalized medicine: computational and statistical challenges
109 ISSN 1741-0541 10.2217/PME.12.1 © 2012 Future Medicine Ltd Personalized Medicine (2012) 9(2), 109–114 “On the road towards in silico humans with in silico diseases that are applicable to treatment prediction in personalized medicine, it is necessary to consider the intermediate steps where statistical models are built for the purposes of both prediction and systems level understanding, from...
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